Provides a variety of services including patient care, diagnostic services, support services, chemotherapy, emergency department, heart health, Planet Heart vascular and heart screening, nursing service, maternity care, medical/surgical, newborn nursery, pediatrics, respite care, swing bed, outpatient treatment, pain management, pregnancy and childbirth, rehabilitation services, cardiac rehab, occupational therapy, physical therapy, speech therapy, sleep study lab, surgical procedures, and telehealth.

Sponsored by Avera, Avera St. Luke's facilities include a hospital and comprehensive retirement communities in Aberdeen and Eureka, and clinics. Services include: addiction care (residential and outpatient services), behavioral health services (inpatient and outpatient), cancer services/medical oncology and radiation oncology, cardiology, dermatology, diabetes care, diagnostic imaging, emergency and trauma care, home health and hospice, Human Performance Center, hyperbaric oxygen treatments (wounds only), kidney dialysis, long-term care, nephrology, OB/GYN, occupational health, orthopedics, pain management, pediatrics, physical medicine and rehab, podiatry, primary care (family practice and internal medicine), primary care clinic (Groton, SD, and Ellendale, ND), pulmonology, same-day sick visit clinic, sleep lab, spine surgery, surgery, after-hours clinic, urology, wellness services, women's specialty services, and wound care.

Services include emergency room, ambulance, cardiac rehabilitation, chronic care management, gastroscopy, intensive/coronary care unit, mammograms, pulmonary rehab, physical, speech, and occupational therapies, and a sleep lab. Provides monthly services for blood pressure/blood sugars, walk-in immunizations, and foot care clinic. Also includes outreach clinics/telemedicine services for a variety of health needs.