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1415 Eglin Street, Target, Rapid City, SD 57701
Offers prescription delivery and pickup, immunization shots, and walk-in and virtual care options. Also offers Sexually Transmitted Infection (STI) screening and treatment, chronic disease self management program, birth control and family planning, and smoking cessation. Rapid City and Sioux Falls - S. Louise Avenue location are a medication disposal site.
6511 W. 41st Street, Sioux Falls, SD 57106
Offers the following services: primary care, birth control, morning-after pill (emergency contraception), breast and chest exams including mammogram referrals if necessary, HIV testing, LGBTQ Services, men's health care, pregnancy testing and services, STD testing/treatment/vaccines, women's health care, gender affirming hormone therapy (GAHT), HPV vaccinations, Hepatitis B vaccinations, and Flu shots. Telehealth visits are available on Tuesdays for some of these services.
2233 6th Street, Brookings, SD 57006
Retail pharmacy and a medication disposal site. Services provided are immunizations, medical equipment/supplies, smoking cessation, and pain management. Also sells OTC medications.
1010 W. 1st Street, Redfield, SD 57469
Offering compassionate and comprehensive care for all patients. Services include annual physicals, immunizations, medication management, transitional care management, joint injections, lesion/wart removal, splinting/casting, and Behavioral Health appointments via telehealth. Same Day Appointments are available during regular business hours Monday to Friday as well as Urgent Care appointments on Saturdays.
1021 S. Highline Place, Target, Sioux Falls, SD 57110
Offers prescription delivery and pickup, immunization shots, and walk-in and virtual care options. Also offers Sexually Transmitted Infection (STI) screening and treatment, chronic disease self management program, birth control and family planning, and smoking cessation. Rapid City and Sioux Falls - S. Louise Avenue location are a medication disposal site.
3209 S. Louise Avenue, Sioux Falls, SD 57106
Retail pharmacy and a medication disposal site. Services provided are immunizations, medical equipment/supplies, smoking cessation, and pain management. Also sells OTC medications.
1730 N. Garfield Avenue, Pierre, SD 57501
Retail pharmacy and a medication disposal site. Services provided are immunizations, medical equipment/supplies, smoking cessation, and pain management. Also sells OTC medications.
1200 N. LaCrosse Street, Rapid City, SD 57701
Retail pharmacy and a medication disposal site. Services provided are immunizations, medical equipment/supplies, smoking cessation, and pain management. Also sells OTC medications.
1207 Princeton Avenue, Vermillion, SD 57069
Retail pharmacy and a medication disposal site. Services provided are immunizations, medical equipment/supplies, smoking cessation, and pain management. Also sells OTC medications.
2791 Dakota Avenue S., Huron, SD 57350
Retail pharmacy and a medication disposal site. Services provided are immunizations, medical equipment/supplies, smoking cessation, and pain management. Also sells OTC medications.
5200 W. 60th Street N., Sioux Falls, SD 57107
Retail pharmacy and a medication disposal site. Services provided are immunizations, medical equipment/supplies, smoking cessation, and pain management. Also sells OTC medications.
1201 29th Street S.E., Watertown, SD 57201
Retail pharmacy and a medication disposal site. Services provided are immunizations, medical equipment/supplies, smoking cessation, and pain management. Also sells OTC medications.
3820 7th Avenue S.E., Aberdeen, SD 57401
Retail pharmacy and a medication disposal site. Services provided are immunizations, medical equipment/supplies, smoking cessation, and pain management. Also sells OTC medications.
801 Lefevre Drive, Target, Brookings, SD 57006
Offers prescription delivery and pickup, immunization shots, and walk-in and virtual care options. Also offers Sexually Transmitted Infection (STI) screening and treatment, chronic disease self management program, birth control and family planning, and smoking cessation. Rapid City and Sioux Falls - S. Louise Avenue location are a medication disposal site.
920 Broadway Avenue, Suite 2, Yankton, SD 57078
Horizon Health - Yankton Medical offers Medical care (behavioral health, geriatric, chronic care management, DOT physicals, physical exams, family medicine, maternal health, family planning, sexually-transmitted disease testing, nursing, health education, immunizations, preventative services, well child exams, acute care, immunizations, lab/x-ray, and women's health). Also offers Certified Application Counselors for the Health Insurance Marketplace. Horizon Health - Yankton Dental offers dental care services include cleanings, dental exams, bridges, crowns, dentures, digital x-rays, emergencies, extractions, fillings, mouth guards, partials, root canals, sealants and spacers.
1401 10th Avenue W., Mobridge, SD 57601
An independent, nonprofit critical access hospital providing the following services: emergency care, cardiac rehabilitation services, coronary care, diabetes counseling, intensive care, in-patient services, obstetrics/childbirth services, occupational therapy, physical therapy, pulmonary care services, radiology services, respiratory therapy, sleep studies, swing bed program, surgical services, and on-site specialty providers (orthopedics, pain management, cardiology, urology, and audiology).
4 19th Street N.E., Watertown, SD 57201
Clinic provides primary care, mental health, home based primary care, and telehealth services. No emergency services are provided at the clinic. Mental Health Services include individual, couples, and group psychotherapy The following programs and specialty care are available by telehealth: Returning Service Member Care Management, PTSD Care, Primary Care, Blind and Low Vision Rehabilitation, Mental Health Care, Military Sexual Trauma Care, and Women Veteran Care.

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5521 E. Arrowhead Parkway, Sioux Falls, SD 57110
Retail pharmacy and a medication disposal site. Services provided are immunizations, medical equipment/supplies, smoking cessation, and pain management. Also sells OTC medications.
339 S. Pierre Street, Pierre, SD 57501
Provides fully integrated medical and behavioral health care services and is a designated Primary Care Provider for Medicaid and Medicaid Health Home. Delivers patient-centered, team-based care, and provides clinical services for: comprehensive ambulatory medical services for all genders and all ages, acute illness and chronic illness management, immunizations, children's well child exams, adult care, women's health, All Women Count, lab services, school/sport/commercial driver license (CDL) physicals, pre-operative exams, preventative cancer screenings, comprehensive diabetes program, health promotion and education, SD plan & family planning services, HIV & STD testing / STI prevention education, and medication assisted treatment, case management, and certified patient navigators. SDUIH is accredited by the Accreditation Association for Ambulatory Health Care (AAAHC) and is a Federally Qualified Health Center (FQHC). Transportation is available for current patients if needed.
3001 Broadway Avenue, Yankton, SD 57078
Retail pharmacy and a medication disposal site. Services provided are immunizations, medical equipment/supplies, smoking cessation, and pain management. Also sells OTC medications.
2825 1st Avenue, Spearfish, SD 57783
Retail pharmacy and a medication disposal site. Services provided are immunizations, medical equipment/supplies, smoking cessation, and pain management. Also sells OTC medications.
100 Stumer Road, Rapid City, SD 57701
Retail pharmacy and a medication disposal site. Services provided are immunizations, medical equipment/supplies, smoking cessation, and pain management. Also sells OTC medications.
1101 E. Spruce Street, Mitchell, SD 57301
Retail pharmacy and a medication disposal site. Services provided are immunizations, medical equipment/supplies, smoking cessation, and pain management. Also sells OTC medications.
2501 W. 22nd Street, Sioux Falls, SD 57105
Providing health care and services to eligible women Veterans. Services include: primary care, gynecology services, infertility care, pregnancy care, contraceptive services, mammography, social work, mental health care, and care for menopausal issues.
380 W. Anchor Drive, North Sioux City, SD 57049
Specialty care include: Audiology, Home Based Primary Care, Lab, Mental Health, Pharmacy clinical services, Physical Therapy, Primary Care, Social Work, and Nutrition. The following programs and specialty care are available by telehealth: Cardiology, Occupational Therapy, Chronic Health Management, Oncology, Dermatology, Orthopedics, Diabetes Management, Pain Management, Endocrinology, Pharmacy Services, Gastroenterology, Prosthetics/Orthotics, Genomic Medicine, Psychiatry, Infectious Disease, Pulmonary, Mental Health, Surgery (pre-op), Nephrology, Low Vision, Neurology, Urology, and Wound Care.​

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